What is DAXXIFY®?

DAXXIFY® (DaxibotulinumtoxinA) is the first and only, long-lasting, peptide-powered neuromodulator FDA-approved for the temporary improvement in the appearance of moderate to severe frown lines in adults.

The active ingredient in DAXXIFY® is a purified protein called botulinum toxin type A.

Is DAXXIFY® for me?

If you are concerned about frown lines? Daxxify® could be a treatment option for you. It is designed to relax those muscles and improve your appearance. It works quickly, lasts a long time, and can give you a refreshed look.

DAXXIFY® is a prescription medicine for adults to temporarily improve the look of moderate to severe frown lines between the eyebrows.

Daxxify before and after photos from Daxxify

Results seen as early as the next day after treatment, typically seen within 2 days.

How is DAXXIFY® different from other frown line treatments?

Unlike other frown line treatments like Botox® Cosmetic and Dysport®, which use human or animal products to stabilize the key ingredient, DAXXIFY® takes a unique approach. It utilizes a specially designed peptide for stabilization, making it a completely vegan option. This peptide helps keep the formula effective for longer, ultimately leading to smoother frown lines.

Daxxify before and after

DAXXIFY® gives patients a better look vs baseline by smoothing even the deepest lines. 64% of patients achieved an improvement in the appearance of skin texture at week 2.

*Results as early as the next day and typically within 2 days. At least 50% of patients in clinical studies had no or minor frown lines for over 4 months after treatment.

Will DAXXIFY®units match my current treatment?

Units are unique. Each treatment (Botox®, Dysport®, DAXXIFY®) has its own unit system for measuring potency. They are like fingerprints – not directly comparable.

A more accurate way to compare doses is by looking at the amount of active ingredient (botulinum toxin type A) in nanograms.

  • Daxxify® example: Approved frown line dose is 40 units amount with 0.18 nanograms of active ingredient.
  • Botox® comparison: Approved frown line dose: 20 Units Amount of active ingredient: 0.18 nanograms.
  • Dysport® comparison: Approved frown line dose: 50 Units Amount of active ingredient: 0.27 nanograms.

As you can see, despite the number of Units, DAXXIFY® isn’t 2x the dose of Botox® Cosmetic and Dypsort® isn’t 2.5x the dose of Botox® Cosmetic. Each product is unique. Talk to one of our Advanced Aesthetic Injectors about DAXXIFY® and your aesthetic goals.
The potency Units of DAXXIFY® are not interchangeable with other preparations of other botulinum toxin products.

It is always best to schedule a consultation with one our experienced injectors to discuss you needs.

Preparing for Your DAXXIFY® Treatment

We’ve compiled key information to address everything from what to expect during your appointment to how long the results might last.

Preparing for TreatmentAsk your injector for specific recommendations. Some common ones include stopping certain medications and supplements a few days before treatment.
Discomfort During InjectionDAXXIFY® uses a small needle, and people often describe the injection as a pinch. If you’re concerned about discomfort, talk to your injector about options like icing the area or numbing cream.
DowntimeDAXXIFY® requires minimal downtime, so you can resume normal activities right after.
Side EffectsThere might be swelling, redness, or tenderness around the injection site, but these usually go away within a few hours or days.
Treatment FrequencyDaxxify® results can last for over 4 months.
Seeing ResultsYou may see results within the next day or two after treatment.

Meet our Advanced Aesthetics Injector Team

When you trust us with your aesthetics, expect a personalized journey. We’ll start with a consultation to understand your goals, followed by a thorough assessment. Then, we’ll work together to create a treatment plan that enhances your natural beauty and addresses your concerns. Contact our office at 678-566-7200 to schedule an in-person consultation at our Midtown Atlanta or Alpharetta office

Daxxify FAQs

Injectable dermal fillers are synthetic gels that are primarily made of hyaluronic acid, hyaluronic acid is a water-loving DAXXIFY® is manufactured in California, and the only prescription frown line treatment made in the United States. Conventional frown line treatments are manufactured in other countries, then imported into the United States. 

In 2002, physicians and entrepreneurs founded a start-up in Silicon Valley, California to explore the use of peptides in biologics for different therapeutic uses. Their goal was to utilize peptides to transport biologics, typically large molecules, through the skin.

The initial idea was to formulate botulinum toxin type A, the active ingredient in DAXXIFY®, with a peptide to see if it could be applied topically to the skin to treat crow’s feet wrinkles. Through this process, scientists discovered that the formulation was optimally administered through injection. Several clinical studies were created to determine the correct dose for an injectable product that would treat frown lines.

DAXXIFY® was studied in the largest-ever clinical study for a frown line treatment and included more than 2,800 people across different ages and skin types. Here are some things you should know about DAXXIFY®:

  • There were no serious treatment-related side effects
  • The active ingredient in DAXXIFY® is botulinum toxin type A, an ingredient that has been used in frown line treatments for more than 20 years

DAXXIFY® may cause serious side effects that can be life threatening. Talk to one of our Advanced Aesthetic Injectors about possible side effects and consult with the Prescribing Information and Medication Guide.

The safety and efficacy of DAXXIFY® is well established, with more than 20 years of research. In fact, DAXXIFY® has been studied in the largest-ever phase 3 clinical trial conducted for a frown line treatment and included more than 2,800 people across different ages and with different skin types. DAXXIFY® was studied in patients with varying skin types.

No, not necessarily. The most common side effects observed in clinical trials occurred within one to two weeks after injection and lasted only a short while. This is consistent with other frown line treatments. DAXXIFY® is well studied, with no serious treatment-related side effects seen in large-scale clinical trials.

You may see results with DAXXIFY® as early as the next day after treatment, and typically within two days. You should see noticeable results within a two-week time frame. You may experience mild injection-related bruising. In most cases, bruising heals within a few days after injection.

DAXXIFY® minimizes the appearance of moderate to severe frown lines by temporarily relaxing the underlying muscles that cause these wrinkles. DAXXIFY® is a long-lasting botulinum type A treatment with a novel peptide.

Facial fillers, also known as dermal fillers, are typically made of hyaluronic acid and are used to add volume, fullness, and structure to areas of the face. They can help contour cheekbones, soften lines around the nose and mouth, and volumize lips. Dermal fillers target volume loss rather than muscle-related wrinkles.

Resource: https://www.daxxify.com/faqs

IMPORTANT SAFETY INFORMATION for DAXXIFY® (daxibotulinumtoxinA-Ianm) injection

DAXXIFY® may cause serious side effects that can be life threatening. Get medical help right away if you have any of these problems any time (hours to weeks) after injection of DAXXIFY®:

• Problems swallowing, speaking, or breathing due to weakening of associated muscles can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months.

• Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms that include loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, and trouble swallowing.

Do not receive DAXXIFY® if you are allergic to any of the ingredients in DAXXIFY® (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA (BOTOX®/BOTOX® Cosmetic), abobotulinumtoxinA (DYSPORT®), incobotulinumtoxinA (XEOMIN®) or prabotulinumtoxinA-xvfs (JEUVEAU®); or have a skin infection at the planned injection site.

DAXXIFY® dosing units are not the same as, or comparable to, any other botulinum toxin product.

Tell your healthcare provider about all your medical conditions, including any side effects from botulinum toxin products, including dry eye; breathing, swallowing, bleeding, or heart problems; plans to have surgery; weakness of forehead muscles; drooping eyelids; have had surgery on your face; are pregnant or breastfeeding or plan to become pregnant or breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using DAXXIFY® with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your healthcare provider that you have received DAXXIFY® in the past.

Especially tell your healthcare provider if you have received any other botulinum toxin product in the last 4 months or any in the past, and exactly which product you received (such as BOTOX®, BOTOX® Cosmetic, MYOBLOC®, DYSPORT®, XEOMIN®, or JEUVEAU®). DAXXIFY® may cause serious side effects, including allergic reactions (such as itching, rash, redness, swelling, wheezing, trouble breathing, or dizziness or feeling faint), heart problems (such as irregular heartbeat and heart attack), and eye problems (including dry eye, reduced blinking, and corneal problems). 

Tell your healthcare provider or get medical help right away if you experience a serious side effect. No serious adverse events of distant spread of toxin effect associated with dermatologic use of DAXXIFY® have been reported in clinical studies at the dose of 40 Units for glabellar lines. The most common side effects of DAXXIFY® include headache, eyelid drooping, and loss of ability to move the muscles in your face.

These are not all the possible side effects of DAXXIFY®. For more information, see the full Prescribing Information including Boxed Warning, and refer to the Medication Guide or talk with your doctor. To report side effects associated with DAXXIFY®, please call 1-877-373-8669. You may also report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.