A Guide to Understanding Semaglutide for Weight Loss

Have you ever wondered if there is a way to achieve rapid and sustainable weight loss without feeling like you’re constantly battling your own body?

With the rise of various weight loss solutions, it’s easy to feel overwhelmed and skeptical about what truly works. One of the latest and most promising options gaining significant attention is Semaglutide.

As a medication initially developed for managing diabetes, Semaglutide has recently been making waves in the weight loss community. Its popularity is skyrocketing, with countless online searches and discussions highlighting its effectiveness. In this guide, we’ll explore what Semaglutide is, how it works, and why it might be the weight loss solution you’ve been searching for.

Setting Realistic Expectations

While the buzz around Semaglutide includes claims of guaranteed weight loss in just four weeks, it’s essential to set realistic expectations. While some individuals may experience noticeable changes early on, Semaglutide works gradually by mimicking a hormone that regulates appetite and food intake.

This means that weight loss with Semaglutide is more about steady and sustainable progress rather than an overnight transformation.

Expecting dramatic results in such a short period can lead to disappointment and frustration. Instead, focus on the long-term benefits and the healthier, more consistent weight loss journey that Semaglutide can facilitate. Understanding this gradual effect can help you stay motivated and committed to achieving your weight loss goals over time.

Who is a Candidate for Semaglutide?

Semaglutide is approved for individuals who meet specific criteria. After speaking with our provider, the patient has lab work done to determine if he/she is a good candidate for the treatment.

The Range of Potential Weight Loss with Semaglutide

When considering Semaglutide for weight loss, it’s important to understand that individual results can vary widely. Factors such as adherence to the medication, lifestyle changes, and individual metabolic differences all play a role in determining the extent of weight loss.

In clinical trials, which typically involved participants taking Semaglutide for 68 weeks or more, participants experienced significant reductions in body weight, often exceeding 10-15% of their starting weight.  

For example, the STEP 1 trial, published in the New England Journal of Medicine in 2021, was a randomized, double-blind, placebo-controlled study that evaluated the efficacy and safety of Semaglutide 2.4 mg (wegovy) for weight management in 1,961 adults. In the trial, participants experienced a clear weight loss timeline:

• Within 4 weeks, they saw an average loss of 3.8% of their initial body weight. In other words, a person weighing 225 pounds would have experienced a weight loss of 8.55 pounds in their first month on Semaglutide.
• By 12 weeks, this increased to 9.6%.
• By 6 months, they had lost about 13.8% of their initial body weight average. 
• After a full year, individuals typically lost 15-17% of their baseline weight, with some achieving even more significant reductions. Long-term results show a sustained loss of 10-15% for most participants. 

The study also showed improvements in cardiometabolic risk factors, such as reduced waist circumference and better glycemic control.

More recently, as published in Nature earlier this year, the Select Study traced the weight loss trajectory of 17,604 patients from 41 countries over 4 years. Study outcomes were similar to those of the STEP 1 Trial and showed sustained weight loss over the 208 weeks as well as significant improvements in cardiometabolic risk factors as compared to participants on the placebo.

What does this mean for you?

Some people may experience more rapid weight loss initially, while others may see slower but consistent progress. It’s crucial to maintain realistic expectations and understand that the journey is unique for everyone.

Healthy, Sustainable Weight Loss vs. Rapid Weight Loss

The goal of weight loss should always prioritize health and sustainability over speed. Rapid weight loss often leads to muscle loss, nutritional deficiencies, and a higher likelihood of regaining the weight. Semaglutide supports a healthier approach by promoting gradual weight loss, which is more likely to be maintained long-term.

Here’s how Semaglutide facilitates this:

• Gradual Approach: By slowly reducing appetite and promoting satiety, Semaglutide helps individuals make manageable changes to their eating habits.
• Sustainable Results: This slow and steady weight loss reduces the stress on the body and supports lasting changes in lifestyle and behavior.
• Long-Term Health Benefits: Achieving and maintaining a healthy weight gradually can lead to better overall health, improved metabolic functions, and a lower risk of weight-related health conditions.

By focusing on sustainable weight loss, Semaglutide can be a powerful tool in your weight management arsenal, helping you achieve your goals in a healthy and enduring way.

If you decide to come to our practice for Semaglutide, you’ll be treated with the utmost care.  Everything is discussed at the consult, from goals and desired weight, to nutrition and exercise and how to achieve it.  I tell the patient everything to expect so there are no surprises but I also tell them that I’ll be there to walk them through the process and they can contact me with any questions and concerns.

Jennifer Braswell, Certified Nutritional Coach and IV Infusion Nurse

What are the Potential Side Effects of Semaglutide?

While Semaglutide can be an effective weight loss aid, it’s important to be aware of the potential side effects. These can range from mild to more serious, and not everyone will experience them. 

Common side effects include:

• Nausea: Often the most reported side effect, especially when starting the medication or increasing the dose.
• Dyspepsia: Due to food staying in the stomach longer, there is a chance for acid indigestion to take place.
• Diarrhea: Another gastrointestinal issue that some users may experience.
• Constipation: Some individuals may find their bowel movements are less frequent.
• Abdominal Pain: General discomfort or pain in the stomach area is possible.
• Fatigue: Some people may feel more tired than usual.

Less common side effects include:

• Dizziness: A feeling of lightheadedness or dizziness, particularly when standing up quickly.
• Vomiting: Some individuals experience vomiting if the dosage has been increased too much and too quickly.
• Hypoglycemia: Low blood sugar levels, especially in individuals also taking diabetes medications.
• Gallbladder Issues: Including gallstones or inflammation of the gallbladder.
• Pancreatitis: In rare cases, inflammation of the pancreas, which can be serious.
• Kidney Problems: In rare instances, worsening of kidney function, particularly in those with preexisting kidney conditions.
• Allergic Reactions: Though rare, some individuals may experience allergic reactions such as rash, itching, or difficulty breathing.

It’s crucial to monitor any new or worsening symptoms and discuss them with a healthcare provider. Side effects may be managed by adjusting the dosage under the guidance of a healthcare professional. Inform your healthcare provider about any preexisting conditions or other medications being taken to avoid potential interactions.

Understanding these potential side effects can help individuals make informed decisions about using Semaglutide and ensure they seek timely medical advice if needed.

Conclusion

Semaglutide represents a promising option for individuals seeking sustainable weight loss solutions. By mimicking natural hormones that regulate appetite and food intake and facilitate a gradual and steady weight reduction, emphasizing long-term health benefits over rapid, short-term results.

It’s crucial to approach Semaglutide treatment with an understanding of its gradual impact, adherence to recommended lifestyle changes, and awareness of potential side effects. By working closely with healthcare providers to tailor the treatment plan to individual needs and monitoring progress carefully, users can maximize the benefits while minimizing risks.

Our Wellness Team Is Here For You

At Dr. Rudderman’s, we understand your concerns about effectiveness, safety, and cost. That’s why we offer a personalized approach to weight management through our Weight Loss and Wellness Program. Don’t let weight loss be a constant struggle. Schedule a consultation to discuss your goals and explore the potential benefits of semaglutide. Fill out the form below and someone from our office will be in contact with you.